Bioactive Small Molecules
![Medchemexpress LLC N-(2-chloro-6-methyl-4-{[(1R)-1-(1-methylpiperidin-4-yl)ethyl]sulfamoyl}phenyl)-2-methylbenzamide | 2756350-98-6 | MFCD00004280 | 98.3% | 464.02 Da | C23H30ClN3O3S | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000222706.png-250.jpg)
Medchemexpress LLC N-(2-chloro-6-methyl-4-{[(1R)-1-(1-methylpiperidin-4-yl)ethyl]sulfamoyl}phenyl)-2-methylbenzamide | 2756350-98-6 | MFCD00004280 | 98.3% | 464.02 Da | C23H30ClN3O3S | 5 MG
CCR8 antagonist 2 is a small-molecule CCR8 receptor antagonist used as a research tool to probe CCR8-mediated signaling in immunology and inflammation studies. It is routinely applied in biochemical and cellular assays to study regulatory T cell and Th2 responses.
- High purity confirmed by HPLC (98.3%).
- Potent CCR8 antagonist activity for receptor-targeted studies.
- Suitable for biochemical and cellular CCR8 assays.
- Soluble in DMSO for easy preparation of stock solutions.
- Molecular weight 464.02 Da; molecular formula C23H30ClN3O3S.
- Stable when stored at -20 °C for long-term storage.
Medchemexpress LLC MYC degrader 1 (compound A80.2HCl) | 2946670-96-6 | 99.6% | 626.07 | 1 MG
MYC degrader 1 (compound A80.2HCl) is an orally available MYC molecular glues degrader that demonstrates anti-tumor activity. It works by restoring pRB1 protein activity and re-establishing the sensitivity of MYC-overexpressing cancer cells to CDK4/6 inhibitors.
- Degrades MYC in various cell lines.
- Reduces the IC50 of Palbociclib in T24 and UMUC14 cells.
- Enhances the inhibition of cell cycle genes and colony formation by Palbociclib in drug-resistant cancer cell lines.
- Inhibits the growth of T24 and UMUC14 xenograft tumors in mice.
- Enhances the inhibitory effect of Palbociclib on tumor growth in T24 xenograft mice.
![Medchemexpress LLC N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide | 978-62-1 | MFCD00218820 | 99.3% | 383.67 g/mol | C15H8ClF6NO2 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000245385.png-250.jpg)
Medchemexpress LLC N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide | 978-62-1 | MFCD00218820 | 99.3% | 383.67 g/mol | C15H8ClF6NO2 | 1 ML
IMD-0354 (IKK2 Inhibitor V) is a small-molecule inhibitor of IKKβ (IKK2) that blocks NF-κB signaling and downstream NF-κB-dependent transcription. It is intended for research use and is available as a solid or as a prepared 10 mM solution in DMSO.
- Selective IKKβ inhibitor that reduces NF-κB activity.
- Reported to inhibit TNF-α-induced NF-κB transcription with an IC50 of ~1.2 μM.
- High purity of approximately 99.3% suitable for research applications.
- Molecular weight 383.67 g/mol for accurate dosing calculations.
- Soluble in DMSO; supplier recommends DMSO at high concentration.
- Available as solid material or as a 10 mM solution in DMSO for convenience.
Medchemexpress LLC Cpk20 | 2397708-22-2 | 99.7% | 506.50 | 25 MG
CPK20 is a potent and highly selective KCNT1 channel blocker. It is intended for research use only and not for sale to patients.
- Potent and highly selective KCNT1 channel blocker.
- Can be used in the study of epilepsy.
Selleck Chemical LLC LXH254 2mg 1800398-38-2
LXH254 is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC HY-114147 5mg Medchemexpress, Tuberculosis inhibitor 3 CAS:2219325-28-5 Purity:>98%
Medchemexpress, HY-114147 5mg Tuberculosis inhibitor 3 CAS:2219325-28-5 Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC < 0.016 µg/mL) against drug-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Saxagliptin hydrate | 945667-22-1 | MFCD26131254 | ≥99.0% | 333.43 | C18H27N3O3 | 100 MG
Saxagliptin hydrate is a potent, selective, reversible, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor used for research into type 2 diabetes and DPP-4 biology. It is offered in solid and solution forms across multiple pack sizes and is intended for research use only.
- Research use only; not for human or clinical use.
- CAS number 945667-22-1.
- Purity typically ≥99.0% (data sheet reports 98.13%).
- Molecular weight 333.43 and formula C18H27N3O3.
- Available as solids (5-100 mg and bulk) and 10 mM solutions in DMSO.
- Supplied quantities suitable for assay development and preclinical research.
Cayman Chemical Ombuin, Purity: ≥98%, CAS: 529-40-8, 5 mg
A flavonoid with diverse biological activities; an antagonist of M1 mAChRs (Ki = 42 µM in CHO-K1 cells expressing the human receptor); cytotoxic to HepG2 cancer cells (IC50 = 1.5 µg/ml); reduces blood urea and glucose levels, urinary volume and protein levels, serum creatinine levels, renal fibrosis levels, and body weight in a rat model of STZ-induced diabetic nephropathy at 40 mg/kg per day
Medchemexpress LLC HY-111669 10mg Medchemexpress, Sigma-2 receptor antagonist 1 CAS:1802632-22-9 Purity:>98%
Medchemexpress, HY-112189 10mg Interferon receptor inducer-1 CAS:2215120-36-6 Interferon receptor inducer-1 (compound 6) is an interferon (IFN) receptor inducer. Used accordingly in the treatment of a disorder in which the induction of interferon is involved. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical NSC 319726, Purity: ≥95%, CAS: 71555-25-4, 25 mg
A p53 reactivator; selectively inhibits growth of human tumor cell lines containing mutant p53 over those containing wild-type p53 (IC50s = 0.1-1 and >10 μM, respectively); induces apoptosis in TOV112D (p53R175H), but not OVCAR3 (p53R248W) or SKOV3 (p53-/-), cells at a concentration of 1 μM; restores a wild-type conformation to human p53175 and mouse p53R172 mutant proteins and induces expression of p53 target genes in TOV112D cells; inhibits tumor growth in TOV112D, but not H460 (p53+/+), mouse xenograft model when administered at a dose of 1 mg/kg; has broad-spectrum antifungal activity (MIC50s = 0.1-2 μg/ml against a panel of pathogenic fungi) with >800-fold selectivity for fungi over human HUH-7 and HepG2 cells
eMolecules 1002801-51-5 | TH10785 | Medchem Express | 267.376 | C17H21N3 | 98 | C1CC1c1nc(NC2CCCCC2)c2ccccc2n1 | 5mg | 721434767
Ambeed | N-Methyl-5-(4455-tetramethyl-132-dioxaborolan-2-yl)pyridin-2-amine | 100mg | 632172356 | A133254 | 1005009-98-2 | MFCD11878220 | 234.110 | C12H19BN2O2
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Medchemexpress LLC HY-D0857 500mg Medchemexpress, HEPES CAS:7365-45-9 Purity:>98%
Medchemexpress, HY-D0857 500mg HEPES CAS:7365-45-9 HEPES, a zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a potent inducer of lysosome biogenesis[2][3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC N-Boc-hexahydro-1H-azepine-4-one | 188975-88-4 | 99.27% | 213.27 | 10 G
N-Boc-hexahydro-1H-azepine-4-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is for research use only and not for sale to patients.
- Biochemical reagent
- Biological material or organic compound for life science related research
- For research use only
AdipoGen AZ 960
Chemical. CAS 905586-69-8. Formula C18H16F2N6. MW 354.4. AZ-960 is a potent, selective and ATP-competitive JAK2 inhibitor that inhibits JAK2 kinase with a Ki of 0.45nM in vitro 3-fold selective over JAK3 and induces growth arrest and apoptosis in adult T cell leukemia ATL cells. Janus-associated kinases JAKs are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2, where a switch from valine to phenylalanine occurs at position 617 V617F. Furthermore, constitutive activation of the JAK2 signaling pathway is associated with aggressive adult T cell leukemia/lymphoma. AZ-960 induces growth arrest and apoptosis of human T cell lymphotropic virus type 1, HTLV-1-infected T cells MT-1 and MT-2 in parallel with downregulation of the phosphorylated forms of JAK2 and Bcl-2 family proteins including Bcl-2 and Mcl-1.
Cayman Chemical DS44960156, Purity: ≥98%, CAS: 2361327-08-2, 5 mg
An MTHFD2 inhibitor (IC50 = 1.6 µM); selective for MTHFD2 over MTHFD1 (IC50 = >30 µM)