Bioactive Small Molecules
Medchemexpress LLC Anticonvulsant agent 2 | 75220-84-7 | C21H17ClN2 | 1 ML
Anticonvulsant agent 2 is a potent and orally active anticonvulsant agent that exhibits antiepileptic activity. It is for research use only and not sold to patients. In vivo studies showed that Anticonvulsant agent 2 decreased locomotor activity in rats with an inhibition rate of 21.01% and demonstrated antiepileptic activity with an inhibition rate of 24.45% in rats.
- Potent and orally active anticonvulsant agent
- Exhibits antiepileptic activity
- Decreases locomotor activity in rats
- Demonstrates antiepileptic activity in rats
- For research use only
Medchemexpress LLC (R)-(-)-Gossypol acetic acid | 866541-93-7 | C32H34O10 | 100 MG
(R)-(-)-Gossypol acetic acid, also known as AT-101 (acetic acid), is the levorotatory isomer of the natural product Gossypol. It functions as a Bcl-2 Family Inhibitor, binding to Bcl-2, Mcl-1, and Bcl-xL proteins with Ki values of 260±30 nM, 170±10 nM, and 480±40 nM, respectively. This compound demonstrates higher potency than (+)-Gossypol in inhibiting cell growth and inducing apoptosis, exhibiting superior growth inhibition in UM-SCC-6 and UM-SCC-14A cell lines compared to (+)-Gossypol.
- Bcl-2 family inhibitor
- Binds to Bcl-2, Mcl-1, and Bcl-xL proteins
- Induces apoptosis and inhibits cell growth
- Effective against head and neck squamous cell carcinomas (HNSCC) cell lines
- Induces apoptosis in HNSCC tumor cells with functional and mutant p53
Medchemexpress LLC Clathrin-IN-4 | 762242-59-1 | C17H18Br2N2O | 100 MG
Clathrin-IN-4 is an analogue of Wiskostatin that acts as a potent inhibitor of clathrin-mediated endocytosis with an IC50 of 2.1 μM. It also functions as a dynamin I GTPase activity inhibitor with an IC50 of 9.1 μM.
- Purity of 99.54%
- Appears as a solid, white to off-white
- Ships at room temperature in continental US
- Recommended storage at 4°C, protected from light
- Soluble in DMSO at 90 mg/mL
Medchemexpress LLC Cyclopropanesulfonamide, N-[4-[5-[[methyl[2-(methylamino)ethyl]amino]methyl]-3-pyridinyl]phenyl]- | 2890765-10-1 | C19H26N4O2S | 5 MG
PRMT6-IN-3 (compound 25) is a selective PRMT6 inhibitor with an IC50 value of 192 nM. It can induce apoptosis in cancer cells and has anticancer activity.
- Selective PRMT6 inhibitor with an IC50 value of 192 nM.
- Induces apoptosis in cancer cells.
- Possesses anticancer activity.
Apexbio Technology LLC DMAT 749234-11-5 10mM (in 1mL DMSO)
DMAT (CAS 749234-11-5) known as 2-dimethylamino-4 5 6 7-tetrabromo-benzimidazole is a small-molecule inhibitor primarily targeting protein kinase CK2 with an IC50 of 0 13 M It also inhibits other kinases notably PKD1 PIM3 and PIM1 CK2 is implicated in the regulation of cell proliferation and survival and is frequently overexpressed in various human cancers In cellular models DMAT induces caspase-mediated apoptosis in breast cancer cells resistant to antiestrogens and suppresses steroid hormone secretion and proliferation in adrenocortical carcinoma cells In vivo studies indicate that DMAT interferes with NF B and Wnt signaling pathways and impairs hepatoma cell growth by targeting CK2 and PIM-3 supporting its utility in cancer research
eMolecules 1454555-29-3 | Medchem Express | LP-935509 | 5mg | 518570997 | HY-117626 | 396.451 | C20H24N6O3
Ambeed | (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-33-diphenylpropanoic acid | 250mg | 552609160 | A167210 | 201484-50-6 | MFCD00672337 | 463.533 | C30H25NO4
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Cayman Chemical -JasmonIc AcId-d5 5mg
An internal standard for the quantification of (±)-jasmonic acid by GC- or LC-MS
Cayman Chemical Tocopherol 5mg
A form of vitamin E with antioxidant and anti-inflammatory properties; traps and detoxifies reactive nitrogen oxide species, including nitrogen dioxide, in cell-free assays; reduces PGE2 synthesis induced by LPS in RAW 264.7 macrophages and by IL-1β in A549 cells (IC50s = 7.5 and 4 μM, respectively); inhibits LPS-induced nitrite release and iNOS expression in RAW 264.7 cells at 10 μM and reduces COX-2 activity in A549 cells pretreated with IL-1β; serum levels are decreased in patients with cardiovascular disease
Medchemexpress LLC Gdc-0310 | 1788063-52-4 | 98.8% | 543.48 g·mol⁻¹ | C25H29Cl2FN2O4S | 5 MG
GDC-0310 is a selective acyl-sulfonamide inhibitor of the human voltage-gated sodium channel Nav1.7, reported with sub-nanomolar potency (IC50 = 0.6 nM). Supplied as a high-purity research compound, it is used in in vitro and in vivo pharmacology and electrophysiology studies; recommended solvent is DMSO.
- Sub-nanomolar potency for hNav1.7 (IC50 0.6 nM).
- High purity (~98.8%) suitable for pharmacology experiments.
- Solid research reagent with reported preclinical ADME and pharmacokinetic data.
- Soluble in DMSO for stock solution preparation.
- Molecular formula C25H29Cl2FN2O4S; molecular weight 543.48 g·mol⁻¹.
Cayman Chemical ANTIBODY JCP251 10mg
A protease inhibitor; inhibits neutrophil elastase at 5 µM; reduces the activity of HIV protease and caspase-3 by 70 and 68%, respectively, at 100 µM in cell-free assays; decreases Aβ40 and Aβ42 levels in HEK293 cells expressing wild-type and Swedish mutant APP (IC50s = ~30 µM for both)
Medchemexpress LLC MS437 5mg | 541535-31-3 | 5 MG
MS437 is a research-grade small molecule that potently stimulates the thyroid-stimulating hormone receptor (TSHR), activating Gsα, Gαq, and Gα12 signaling and up-regulating thyroglobulin, the sodium iodide symporter, and TSHR gene expression. It is supplied as a high-purity solid for biochemical and cell-based research applications.
- High purity (98.0%).
- Molecular formula C22H24N2O; molecular weight 332.44 g·mol⁻1.
- Potent TSH receptor stimulation (EC50 ≈ 1.3 x 10⁻7 M).
- Available in multiple milligram sizes, including 5 MG.
- Suitable for biochemical assays and cell-based receptor pharmacology studies.
Medchemexpress LLC Psi-6206 | 863329-66-2 | C10H13FN2O5 | 1 ML
PSI-6206 (RO 2433) is a deaminated derivative of PSI-6130, known as a potent and selective inhibitor of HCV NS5B polymerase. While it exhibits low potency in inhibiting HCV replicon with an EC90 of >100 μM, its 5'-triphosphate form (RO2433-TP) effectively inhibits RNA synthesis by both native HCV replicase and recombinant HCV polymerase NS5B. It has shown no activity or cytotoxicity in various anti-HCV assays.
- Deaminated derivative of PSI-6130
- Potent and selective inhibitor of HCV NS5B polymerase
- Exhibits low potency in inhibiting HCV replicon (EC90 >100 μM)
- No activity or cytotoxicity observed in anti-HCV assays
- 5'-triphosphate form inhibits RNA synthesis by native HCV replicase and recombinant HCV polymerase NS5B
- Purity: 99.89%
- Molecular weight: 260.22
Medchemexpress LLC Bivamelagon | 2641595-54-0 | C35H53ClN4O4 | 1 ML
Bivamelagon is an orally active MC4R agonist, characterized by an EC50 of 0.562 nM in the Luci assay and 36.5 nM in the cAMP assay, with a Ki of 65 nM. This compound is suitable for research into conditions such as obesity and diabetes.
- Orally active MC4R agonist
- Effective for research in obesity and diabetes
- Exhibits β-arrestin recruitment activity
- Demonstrates weight-loss activity in mouse obesity models
- High solubility in DMSO
- Purity of 98.72%
eMolecules 1665195-94-7 | Medchem Express | BAZ2-ICR | 5mg | 506404099 | HY-19336 | MFCD28166490 | 357.421 | C20H19N7
Ambeed | 3-(3-Nitrophenyl)propan-1-amine | 250mg | 596569457 | A955109 | 238431-54-4 | MFCD09912929 | 180.207 | C9H12N2O2
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Cayman Chemical YVADCHOtrIfluoroacetAT sa 5mg
A caspase-1/ICE inhibitor; prevents ICE-like and CPP32-like proteinase activity and inhibits apoptosis induced by ceramide or irinotecan in 4B1 cells at 600 µM; prevents chromogranin A-induced cell death of primary rat microglia at 100 µM